CORDIS Project
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This project focuses on developing tools to interpret genetic data from large-scale studies of brain disorders. It aims to bridge the gap between genetic findings and biological mechanisms, facilitating functional experiments to improve understanding and treatment of these disorders.
Genome-wide association studies (GWAS) of unprecedented sample size have recently provided robust insight into the polygenic architecture of many different brain disorders.
Despite this exciting potential, GWAS results have rarely translated into mechanistic disease insight.
This is because the detected genetic effects are small and numerous, and hardly ever directly actionable for functional follow-up.
In addition, the polygenic nature of brain disorders comes with large genetic heterogeneity,…
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