CORDIS Project
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This project investigates the immune response in the intestine, focusing on dendritic cells and their interactions with bacteria. Using advanced imaging techniques, the research aims to understand how these immune cells contribute to gut health and the development of conditions like inflammatory bowel disease.
Dendritic cells (DCs) resident just beyond the epithelial cells (ECs) monolayer are able to extend dendrites from the lamina propria across ECs into the intestinal lumen to capture bacteria (1-3).
During my post-doctoral studies, I visualized in vivo (1), for the first time, by two-photon (2P) intravital microscopy, the ability of intestinal DCs to project dendrites into the lumen to capture lumenal antigens. I associated this response to epithelial Toll-like receptor (TLR) triggering, providing…
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