CORDIS Project
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This project focuses on understanding enteroendocrine cells (EECs) in the human intestine, utilizing gut organoids and advanced genetic techniques. It aims to map EEC subtypes, their functions, and interactions, ultimately contributing to new treatments for metabolic diseases linked to diet.
Intestinal epithelium consists of self-renewing crypt-villus units and contains 6 mature cell types:
Enterocytes, goblet cells, Paneth cells, Tuft cells, M cells and Enteroendocrine cells (EECs).
The rare EECs are subclassified by the (>20) hormones they produce.
Generally, EECs sense intestinal content and regulate gastrointestinal activity, systemic metabolism and food intake.
While one EEC hormone, GLP1, has been developed into a highly successful diabetes drug, a paucity of laboratory models…
F. HOFFMANN-LA ROCHE AG
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