CORDIS Project
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The GUT-NAT project focuses on engineering the gut bacterium Clostridium leptum to produce therapeutic natural products. By enhancing its genetic capabilities, the project aims to create a robust platform for developing new treatments for various health conditions, particularly in cancer therapy.
Recent advances in synthetic biology and microbiome research have highlighted the pivotal role of the human gut microbiome not only in maintaining gastrointestinal health but also in regulating systemic processes such as metabolism, immunity, and neurobiology.
In this context, engineering commensal bacteria for precise, localized therapeutic delivery with minimal side effects is an emerging frontier.
To date, most engineered microbial therapeutics have focused on probiotic species such as Escher…
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