CORDIS Project
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This research investigates the role of the Deleted in Colorectal Cancer receptor in cellular communication, focusing on how it integrates signals from netrin and draxin. The project aims to elucidate the mechanisms of cell migration and organization, which are crucial for proper neural and vascular development.
Secreted proteins and their receptors underlie the communication networks of multicellular organisms and guide the proper organization of developing tissue.
An essential process involves the human transmembrane receptor and signal integration hub, Deleted in Colorectal Cancer (DCC).
Emerging evidence indicates that the netrin and draxin guidance cues are secreted by neighboring cells and form competitive and complex multivalent interactions with DCC.
The DCC receptor thus integrates multiple inp…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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