CORDIS Project
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This project investigates the MORC3-MRE pathway, a newly identified mechanism in mammalian immunity that detects virulence factors from pathogens. By exploring the genetic and molecular aspects of this pathway, the research aims to enhance understanding of immune responses and pathogen recognition.
Successful pathogens use virulence factors to inhibit immune defenses.
To counteract this, host guard proteins monitor the integrity of pathways (guardees) that are attacked by virulence factors, such that inhibition of the guardee activates guard-driven immunity.
Instead of directly detecting microbial components like canonical innate immune (pattern recognition) receptors, guards are activated by sensing the activity of virulent microbes.
While guard-immunity is common in plants, only a few ma…
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