CORDIS Project
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This research investigates the role of γ-secretase in Alzheimer's disease, focusing on how different isoforms of presenilin influence the production of amyloid β peptides. The project aims to understand the localization and substrate specificity of these complexes to inform drug development.
In Alzheimer disease (AD) one of the key players is γ-secretase, a protease that cleaves amyloid precursor protein (APP) within its transmembrane domain to produce amyloid β (Aβ).
Longer Aβ peptides have stronger tendency to aggregate, form plaques and cause inflammation - the direct causes of AD. γ-secretase activity is confined to a complex consisting of presenilin (PSEN), nicastrin (NCT), APH-1 and PEN-2.
The existence of two PSEN isoforms (1&2) and several APH-1 isoforms implies heterogeneit…
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