CORDIS Project
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This project explores the role of the Nanog protein in the self-renewal of embryonic stem cells. It aims to understand how fluctuations in Nanog levels affect gene expression and chromatin interactions, which are crucial for maintaining stem cell properties.
Self-renewal of embryonic stem (ES) cells depends on the activity of a network of transcription factors at the centre of which lies the triumvirate of Nanog, Oct4 and Sox2 that bind together to a multitude of target genes to either activate or repress their expression.
Nanog was initially isolated by the host laboratory on the basis that elevating its expression increased ES cell self-renewal efficiency.
Surprisingly however, the host laboratory further demonstrated that ES cells continue to sel…
THE UNIVERSITY OF EDINBURGH
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