CORDIS Project
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This project focuses on understanding how immune cells navigate chemical gradients, which is crucial for their function in development and disease. By employing advanced imaging and genetic techniques, it aims to uncover the mechanisms behind cell movement in response to these signals.
Gradients of extracellular signalling molecules are a central concept in biology: for example gradients of guidance-cues such as chemokines position migrating cells in development, malignancy and immunity.
Because immune cells are permanently motile, their function most critically depends on spatiotemporal orchestration by a large family of chemokines.
To specify direction, concentration differences of the chemokine need to be interpreted by the migrating cell.
Most mechanistic knowledge about e…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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