CORDIS Project
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This project develops a 3D neuromuscular organoid model to study the interactions between spinal cord neurons and skeletal muscle cells. It aims to understand the mechanisms behind neuromuscular diseases like spinal muscular atrophy and amyotrophic lateral sclerosis, facilitating drug screening and potential treatments…
Locomotion results from the interaction between muscles and the nervous system.
Dysfunction of such cells results in deadly diseases such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
These diseases often show regional selectivity but the underlying reasons remain obscure due to the lack of a suitable model system.
In previous work of my laboratory, we established a 3D neuromuscular organoid (NMO) model that allows the simultaneous generation of spinal cord neurons a…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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