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SWEET DEGRADATION aims to develop new strategies for targeted protein degradation of carbohydrate processing enzymes located in the Golgi apparatus. This could lead to innovative treatments for diseases related to glycan metabolism.
Oligosaccharides and glycoconjugates, a hugely diverse class of biomolecules, are closely associated with health and many diseases.
Carbohydrate metabolism relies mainly on glycosidases and glycosyltransferases which are carbohydrate processing enzymes (CPEs) that break and create glycosidic bonds, respectively.
Controlling their activities is vital for understanding pathological processes in, and developing therapeutics for glycan-related diseases.
Recently, new targeted protein degradation (TP…
UNIVERSITEIT LEIDEN
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