CORDIS Project
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This project studies the glymphatic system's role in drug delivery for central nervous system diseases. It aims to enhance drug availability in the brain using advanced techniques to understand how the glymphatic pathway can improve treatment efficacy.
The prevalence of neurological diseases in the world is greatly increasing.
However, drug development for central nervous system (CNS) diseases is difficult due to its protected nature behind the blood-brain barrier.
The recently discovered glymphatic pathway consists of a para-arterial cerebrospinal fluid influx path and a para-venous interstitial fluid clearance route, coupled through convective flow of interstitial fluid supported by astrocytic aquaporin 4 (Aqp4) water channels.
This macrosco…
KOBENHAVNS UNIVERSITET
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