CORDIS Project
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This project investigates the role of glycosylation in pancreatic ductal adenocarcinoma, a highly aggressive cancer. By analyzing specific glycoproteins and their modifications, the research aims to uncover mechanisms that drive cancer progression and identify potential biomarkers for improved diagnosis and treatment.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancer type, with a 5-year survival rate of just 10%.
This is primarily due to late-stage diagnosis and resistance to current treatments.
Therefore, understanding the molecular mechanisms driving PDAC progression is critical for developing more effective diagnostic and therapeutic approaches.Glycosylation, one of the most prevalent post-translational modification, is fundamentally altered in PDAC.
The two clinically sign…
THE FRANCIS CRICK INSTITUTE LIMITED
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