CORDIS Project
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This project investigates glycosylation reactions, aiming to enhance understanding and control of oligosaccharide synthesis. By analyzing donor glycosides and acceptors, it seeks to develop predictable glycosylation methods for carbohydrate chemistry.
This proposal aims to understand and control glycosylation reactions.
In a glycosylation reaction a “donor” glycoside and an “acceptor” (the nucleophile) are united to form an oligosaccharide.
Although it is the central reaction in carbohydrate chemistry, our understanding of this reaction, in terms of stereoselectivity and productivity is still limited.
The structural variation in the building blocks leads to a complex continuum of SN2-SN1 mechanisms that operates and it is currently impossible…
UNIVERSITEIT LEIDEN
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