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The GlycoGuard project explores how pathogens interact with gut cells via glycosphingolipids. It aims to uncover the molecular mechanisms behind this interaction, enhancing our understanding of mucosal immunity and paving the way for new infection therapies.
Pathogens exploit glycosphingolipids (GSLs) on the surface of gut epithelial cells to initiate infection. A recent breakthrough has uncovered a novel, cell-autonomous immune response in which multivalent clustering of GSLs by bacterial toxins or viruses triggers the degradation of the cell polarity protein PARD6B, leading to reduced pathogen uptake.
This novel GSL-PARD6B pathway highlights the critical role of GSLs in mucosal immunity.
However, the precise molecular mechanisms by which GSL bindi…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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United States, Baltimore
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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