CORDIS Project
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This project investigates how changes in mucin glycosylation affect mucus barrier function and gut microbiota in response to unhealthy diets. It aims to develop new tools to detect specific glycan structures, enhancing our understanding of their role in intestinal diseases like inflammatory bowel disease and cancer.
In the healthy intestines, mucus acts as a barrier that separates the host epithelium from the microbiota and intestinal contents, as well as a habitat for commensal microbes.
The major component of intestinal mucus, MUC2, is heavily O-glycosylated.
Mucin O-glycans are critical for mucus barrier function and host-microbe interactions.
Alterations to mucin glycosylation have been associated with diseases such as inflammatory bowel disease and cancer, and represent a novel target for therapeutic i…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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