CORDIS Project
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Glue2Degrade explores the potential of molecular glues to induce protein degradation, expanding the range of targetable proteins beyond conventional methods. This project aims to identify novel molecular glues and their associated E3 ligases for therapeutic applications.
Traditional drug design relies on inhibition of enzymes or receptors with accessible hydrophobic pockets.
The concept of proteolysis targeting chimeras (PROTACs) promised to overcome this limitation.
Following our discovery of the first PROTAC that induced selective protein degradation in vivo, this technology has seen a boost in academia and industry.
Despite global research efforts, advances are so far incremental: (i) most focus is on degrading targets that can be liganded and are druggable w…
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