CORDIS Project
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This project investigates the role of the glucocorticoid receptor in triple negative breast cancer, focusing on its influence on lipid metabolism and cancer cell behavior. By studying patient-derived organoids, it aims to uncover the molecular mechanisms behind cancer aggressiveness and identify potential therapeutic s…
Triple negative breast cancer (TNBC) is the most aggressive and lethal breast cancer subtype, but it lacks expression of the estrogen receptor, the canonical driver of breast cancer development and progression.
This indicates that there may be other molecular drivers in this context.
The glucocorticoid receptor (GR) is a candidate oncogenic factor in TNBC, that has been shown to support TNBC cell proliferation and metastatic spread.
Therefore, GR antagonism may be a viable strategy to attenuate…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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