CORDIS Project
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This project aims to elucidate the activation mechanisms of glutamate receptors, which are crucial for brain function. By studying receptor dynamics at a molecular level, the research seeks to inform the development of therapeutic interventions targeting excitatory synapses.
Glutamate receptors are amongst the most important signalling molecules in the brain.
Activation of receptors by the neurotransmitter glutamate is required for nervous system function, underlying cognition, learning, memory and sensation.
Despite advances in the study of their structural biology and physiology, how glutamate receptor complexes are activated remains unclear.
With this proposal, we aim to determine how receptor activation and desensitisation are driven by glutamate binding.
Our ce…
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