CORDIS Project
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This project focuses on developing a new imaging method to monitor changes in glutamate metabolism in the human brain, particularly in response to ketamine treatment for treatment-resistant depression. The technique aims to enhance understanding of ketamine's effects and could be applied to other glutamatergic therapie…
While clinical experience confirmed ketamine, a glutamate (Glu) N-methyl-D-aspartate receptor antagonist, as a potent therapy of treatment-resistant major depressive disorder (TRD), the exact mechanism of ketamine’s action in the brain is unclear.
Thus, a method to reliably and reproducibly monitor minute changes in Glu metabolism in the human brain is urgently needed to understand ketamine dynamics in vivo.
So far, the pioneering work at the Medical University Vienna (MUW) showed ketamine-indu…
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