CORDIS Project
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This project investigates how G-quadruplex DNA structures and RNA-DNA hybrids affect DNA processes like replication and transcription. By creating a system to study these interactions in living cells, it aims to uncover mechanisms that protect cells from conflicts that could lead to genetic disorders and cancer.
Maintenance of genome stability is challenged by obstacles that interfere with normal progression of essential DNA-associated transactions, such as DNA replication and transcription.
One such obstacle is the G-quadruplex (G4) DNA secondary structure, which can form in G-rich repetitive DNA sequences.
Transcribed G4-DNA loci often co-exist with stable RNA-DNA hybrids (R-loops), potentially causing deleterious transcription-replication conflicts (TRCs).
Therefore, the ability of cells to mitigate…
THE FRANCIS CRICK INSTITUTE LIMITED
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