CORDIS Project
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This project investigates the complex interactions between gene sequences and transcription factors that regulate gene expression. By mapping binding sites in closely related species, it aims to uncover the rules governing these interactions, contributing to our understanding of phenotypic variation.
Phenotype is a manifestation of a complicated relationship between the gene sequence that dictates the “what” of gene expression and regulatory elements that supply the crucial “when, where, and how.” The central components of gene regulation are transcription factors (TFs) – proteins that regulate transcription by binding to DNA regions adjacent to the gene.
While TFs recognize specific DNA sequences, we do not fully understand the rules that allow regulators to distinguish among the millions o…
CANCER RESEARCH UK LBG
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