CORDIS Project
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This project investigates how glycogen metabolism in astrocytes influences neuronal activity and excitability, particularly under normal and seizure-prone conditions. By studying awake mice, it aims to clarify the role of astrocytic glycogen in maintaining brain ion balance and its implications for epilepsy.
We do not yet fully understand the cellular basis of brain energy metabolism.
The high energy consumption of mammalian brain sets information processing under critical metabolic constraints.
Energy efficiency in brain signaling is supported by functional and metabolic interactions between neuronal and astrocytic cells.
Specifically, during neuronal activity astrocytes rapidly take up neuronally-released compounds from the extracellular space, including potassium (K+) and transmitter molecules. T…
KOBENHAVNS UNIVERSITET
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