CORDIS Project
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This project focuses on developing novel probes to inhibit the MDM2 protein, which regulates the p53 tumor suppressor. By linking these probes to fluorescent markers, the research aims to track their effects on glioma stem cells and enhance treatment strategies for brain tumors.
Mouse double minute 2 homolog (MDM2) is a primary antagonist of p53 tumour suppressor, and MDM2 inhibition represents an attractive way to restore p53 function.
Peptidomimetics which are based on p53 sequence-derived structure, are one of the most promising tools for mimicking MDM2/p53 interaction.
Varying structure of peptidomimetics gives opportunity to measure effect of fine structure changes on inhibition process.
Linking peptidomimetics with fluorophores represents an attractive way to spat…
RUDER BOSKOVIC INSTITUTE
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