CORDIS Project
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This project develops patient-derived cerebral organoid models to study the interactions between neurons and high-grade gliomas. By examining synaptic connections and their role in tumor progression and seizures, the research aims to uncover potential therapeutic targets for treatment.
Pediatric-type diffuse high-grade gliomas are the primary cause of cancer-related mortality in children and adolescents.
The most common and aggressive forms harbor mutually exclusive mutations in histone 3 (H3), involving distinct brain regions and developmental origins.
In contrast to other gliomas, GABAergic interneuron progenitors are implicated as the cells of origin for H3G34-mutant diffuse hemispheric gliomas (DHGs), which almost exclusively affect the cerebral hemispheres.Seizures are a…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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