CORDIS Project
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The GLI-AGE project investigates the role of glial cells in age-related muscle loss, known as sarcopenia. By using advanced imaging and sequencing technologies, it aims to map glial cell activity in aged muscle and identify potential therapeutic targets to improve muscle health in older adults.
Sarcopenia, marked by the progressive loss of muscle mass and strength due to aging, presents a significant public health challenge.
Despite its increasing prevalence, treatment options remain limited, focusing primarily on exercise and nutraceuticals.
Sarcopenia shares several pathological features with nerve injury-induced muscle atrophy, including neuromuscular junction (NMJ) degeneration.
Recent studies have shown that muscle-resident Plp1+ glial cells rapidly activate a neurotrophic program…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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