CORDIS Project
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This project explores the evolutionary biology of aging by manipulating germline signaling in nematodes and zebrafish. It aims to understand how increased investment in somatic cells affects germline maintenance and offspring fitness, challenging traditional views on the survival-reproduction trade-off.
The trade-off between survival and reproduction lies at the core of the evolutionary theory of ageing.
Removal of germ cells extends somatic lifespan implying that reduced reproduction frees up resources for survival.
Remarkably, however, the disruption of germline signalling increases lifespan without the obligatory reduction in fecundity, thus challenging the key role of the survival-reproduction trade-off.
Recent breakthroughs suggest that protection and repair of the genome and the proteome…
UNIVERSITY OF EAST ANGLIA
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