CORDIS Project
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This project explores the relationship between germline activity and lifespan in the model organism C. elegans. By manipulating germline stem cells, the research aims to identify signals that influence aging, potentially shedding light on similar mechanisms in vertebrates and their implications for human longevity.
Trade-offs between reproduction and lifespan are observed in many organisms, however little is known about their underlying molecular and cellular mechanisms.
In C. elegans, when germ cell precursors are removed by laser microsurgery, animals live up to 60% longer than normal.
This longevity is not a simple consequence of sterility, as removing the entire gonad does not extend lifespan, suggesting that the germline and somatic gonad produce opposing signals that are pro-aging and anti-aging, res…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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