CORDIS Project
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This project investigates the genetic and epigenetic factors contributing to Type 2 Diabetes (T2D). By analyzing familial cases and DNA methylation patterns, it aims to uncover novel genetic causes and their impact on insulin secretion.
Failure to elucidate Type 2 Diabetes (T2D) physiology frustrates efforts to improve therapeutics.
Although GWAS has identified 40 T2D genes, mostly expressed in pancreatic beta-cells, this explains no more than 10% of T2D inheritance.
Up to 5% of T2D patients have dominantly inherited maturity-onset diabetes of the young (MODY), characterized by beta-cell dysfunction.
Elucidating the genetics of familial early-onset T2D, using Whole-Exome Sequencing (WES) can bring breakthroughs in understanding…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
France, LILLE
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
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