CORDIS Project
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This project focuses on developing a universal genome editing platform that allows precise gene corrections without introducing errors. It aims to create a system that can be applied across various cell types to address genetic defects safely and efficiently.
Recent breakthroughs in the field of genome editing provide a genuine opportunity to establish innovativeapproaches to repair DNA mutations to replace, engineer or regenerate malfunctioning cells in vitro or invivo.
However, most of the recently developed technologies introduce double-strand DNA breaks at a targetlocus as the first step to gene correction.
These breaks are subsequently repaired by one of the cell intrinsicDNA repair pathways, typically inducing an abundance of insertions and del…
TECHNISCHE UNIVERSITAET DRESDEN
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