CORDIS Project
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This project investigates how DNA damage affects aging and longevity using the model organism Caenorhabditis elegans. By exploring genetic pathways related to DNA repair and longevity, the research aims to identify new genes that could lead to therapies for age-related diseases and progeroid syndromes.
Genome Instability has been recognized as causal factor of cancer and recently also as a major contributing factor of aging. A number of progeroid (premature aging-like) syndromes are linked to defects in nucleotide excision repair (NER). NER thus provides a highly relevant experimental system to study the role of genome stability in aging.
Using the NER system we recently uncovered a novel link between DNA damage accumulation and the regulation of longevity assurance programs.
We propose to use…
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Germany, Koln
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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