CORDIS Project
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This project aims to connect different approaches to understand bacterial adaptation, focusing on the genetic basis of phenotypic complexity. By integrating system biology with experimental evolution, it seeks to uncover the factors influencing bacterial evolution and antibiotic resistance.
The dramatic success of infectious agents comes from their ability to adapt to both immune and pharmaceutical selective pressures.
To uncover the dynamics of bacterial adaptation, experimental evolution has been widely used, focusing mostly on organismal fitness.
Many of the observation derived from these experiments have been captured by Fisher's Geometric model of Adaptation (FGMA).
Despite its success, this top-down phenotypic model is relatively abstract.
In fact, its most important paramete…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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