CORDIS Project
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This project investigates how transcription factors interact with chromatin to influence gene expression. By examining the binding dynamics of these factors in mammalian cells, the research aims to uncover the mechanisms that determine chromatin sensitivity and the accessibility of DNA motifs critical for gene regulati…
Transcription factors (TFs) read cis-regulatory information encoded in the genome and by doing so, they establish gene expression patterns.
However, TFs must compete with structural chromatin proteins such as nucleosomes for access to DNA, and this may partially explain why only a fraction of their sequence motifs in the genome are actually bound.
It is unclear what features discriminate used from unused sites with similar motifs, in vivo, though it is likely that sensitivity of TFs to chromatin…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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