CORDIS Project
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This project investigates the Notch signaling pathway's role in T cell development. By employing advanced techniques like ChIP-Seq and RNA-Seq, it aims to systematically identify Notch targets and their functions during T cell differentiation, providing insights into immune cell development.
The Notch pathway regulates numerous cell fate decisions throughout the development of a multicellular organism.
One well-characterized Notch-dependent differentiation process is the development of T cells.
Notch functions as the T lineage commitment factor at the early stages of differentiation and is required for survival, proliferation and further developmental progression later on.
Although the importance of Notch signaling in T cell differentiation is long-established and some information o…
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