CORDIS Project
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This project seeks to discover new antibiotics by exploring a unique biosynthetic gene cluster that produces a hybrid natural product combining two peptide classes. The research involves genome mining and structural analysis to understand the mechanisms of antibiotic action against resistant bacteria.
Antimicrobial resistance (AMR) is a growing global threat, with the World Health Organization highlighting Gram-negative pathogens as a critical priority.
New antibiotics with innovative modes of action are urgently needed.
This project aims to discover and characterize a previously unexplored biosynthetic gene cluster predicted to encode a hybrid natural product that links two major peptide classes: ribosomally synthesized and post-translationally modified peptides (RiPPs) and nonribosomal pept…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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