CORDIS Project
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This project investigates how cancer cells acquire stem cell traits that enable metastasis. By exploring the relationship between cell movement and metabolic regulation, it aims to identify new targets for cancer treatment.
The major causes of cancer deaths are relapse and resistance to current therapies associated with the presence of cancer stem cells (CSCs) and metastatic growth in distant organs. CSCs have the ability to self-renew and differentiate in non-CSCs.
In breast cancer, acquisition of stemness properties has been closely related to epithelial-mesenchymal transition (EMT), a key process in cancer invasion and metastasis triggered via Rho-ROCK mediated actomyosin contractility.
Interestingly, in melanom…
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