CORDIS Project
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This project explores the role of genomic instability in the early stages of human cancer development, particularly in precancerous lesions. It focuses on the effects of DNA replication stress and short telomeres, aiming to identify potential targets for cancer therapy through extensive genomic analysis.
Genomic instability is a characteristic of practically all human cancers.
Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions.
In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites.
Because common fragile sites are very sensitive to perturbations in DNA replication, we proposed that cancer develop…
UNIVERSITE DE GENEVE
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Finland, HELSINGIN YLIOPISTO
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III
Spain, Madrid
Type: Research institute
Activity type: Research Organisations
SME: No
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