CORDIS Project
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This project aims to uncover the genetic factors contributing to systemic lupus erythematosus (SLE) by conducting a large-scale genome-wide association study involving 5,500 cases from diverse European populations. The research will analyze genetic data to identify novel associations and explore their functional implic…
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mediated by autoantibodies, which recognize nuclear and tissue specific antigens.The aetiology of this disease is incompletely determined.
However, the risk to SLE has a significant genetic component, a conclusion supported by successful genome wide association studies (GWAS) in SLE published since 2008 - all were conducted in US-based cohorts.
The variability within the“top hits” generated by each GWAS indicates the lack of p…
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