CORDIS Project
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This project investigates cellular senescence, a process that prevents tumor development by halting cell proliferation. By inducing specific genes in mice, researchers aim to study the effects of senescence on aging and tissue physiology, providing insights into cancer prevention mechanisms.
Cellular senescence is a central biological mechanism for cancer prevention in mammals.
Cells enter senescence when tumor-inducing genes are aberrantly activated, and in response undergo an arrest in proliferation accompanied by dramatic changes in metabolism and morphology, thus preventing their further development into tumors.
Various types of physiologic stresses can also induce senescence, and this process is thought to play a central role in promoting aging, possibly by limiting the prolife…
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