CORDIS Project
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This project explores the mitotic exit network in yeast, focusing on how specific proteins localize asymmetrically during cell division. It aims to uncover the mechanisms that control this localization and its implications for cell cycle progression and tumor formation.
The mitotic exit network (MEN) is a signaling pathway that promotes exit from mitosis in Saccharomyces cerevisiae by maintaining the protein phosphatase Cdc14 released from the nucleolus into the nucleus and the cytoplasm, where it eventually promotes mitotic cyclin degradation. MEN resembles a RAS-like signaling cascade.
The GTPase Tem1 and the two component GTPase-activating protein Bfa1-Bub2, which function at the top of the MEN, have been shown to localize only to the spindle pole body (SPB,…
UNIVERSIDAD DE SEVILLA
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