CORDIS Project
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This project aims to differentiate growth hormone-releasing hormone neurons from human embryonic stem cells to better understand growth hormone deficiency. By employing advanced gene activation techniques, it seeks to create a model for studying the genetic causes of this condition and aid in drug discovery for growth-…
Hypothalamic growth hormone-releasing hormone (GHRH) neurons stimulate pulsatile pituitary growth hormone (GH) secretion and thereby determine glucose homeostasis and growth in children and eventually adult height.
Conversely, growth hormone deficiency is potentially lethal in neonates, and can lead to short stature and significant morbidity later in life.
However, the mechanisms of growth hormone deficiency are incompletely understood, since pituitary cells and hypothalamic GHRH neurons are vir…
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