CORDIS Project
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This project explores the use of CRISPR-Cas9 gene-editing technology to address cognitive impairments in Down syndrome by manipulating gene networks in neuronal progenitors during early brain development. It aims to develop safer gene therapy methods for potential future applications.
Neurodevelopmental disorders (ND) are chronic psychiatric conditions with different etiologies, but most share a strong genetic component, defective brain development, and cognitive impairment.
Currently, treatment options are very limited, and early educational intervention is the cornerstone for the management of cognitive impairment in most ND, indicating the positive effect of early actions during brain development.
Among ND, Down syndrome (DS) is caused by the presence of an extra chromosom…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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