CORDIS Project
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This project investigates the evolutionary dynamics of gene duplication, challenging existing beliefs about their roles in genetics and disease. It aims to understand how different types of gene duplications influence gene expression and evolutionary pathways, with implications for understanding genetic diseases.
Duplicate genes are important in disease, are a hugely important source of evolutionary novelty, and for many years we thought we understood them.
We thought that duplication relieved selective constraints.
We thought that gene knockout neutrality was due to redundancy.
We thought that a duplicate is a duplicate is a duplicate.
Evidence is accumulating challenging each of these views.
Rather than being the result of an unbiased process, the genes that tend to duplicate in our genome and others a…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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