CORDIS Project
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This project investigates the genetic factors contributing to melanoma development and drug resistance, particularly focusing on the BRAFV600E mutation. By utilizing innovative mouse models, it aims to identify additional mutations that promote cancer progression and resistance to targeted therapies, ultimately seeking…
Melanoma is among the most common and deadly human cancers.
It kills more than 2000 people in the UK every year but an effective cure for metastatic disease does not exist yet.The mutation of valine to glutamic acid at position 600 (V600E) of the BRAF kinase is found in over 60% of human melanomas, establishing it as a prominent oncogene in melanoma.
Since this mutation is also commonly identified in benign and dysplastic nevi, the hypothesis is that additional mutations are required to induce m…
GENOME RESEARCH LIMITED
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