CORDIS Project
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This project investigates the interaction between gamma-delta T cells and a novel ligand on cancer cells to develop new cancer therapies. The focus is on understanding the molecular mechanisms of this interaction to create effective therapeutic agents.
Gamma-delta (gd-)T cells are a fast acting subset of T cells that recognize a wide variety of ligands.
In contrast to alpha-beta T cells they are not restricted to classical peptide-MHC antigens.
Our preliminary data on a gd-T cell clone shows selective recognition of tumour cells mediated through a novel ligand.The aims of this action are; 1) elucidating the molecular mechanism of the gd-T cell receptor (TCR) recognizing the novel ligand on cancer cells and 2) generating therapeutic agents for…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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