CORDIS Project
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This project investigates the dual effects of glucocorticoids on the nervous system, particularly their role in both protecting and harming neuronal survival during stress. It aims to understand the mechanisms behind these contrasting effects to improve clinical applications of glucocorticoids.
Glucocorticoids (GCs), the adrenal steroid hormones released during stress, can have an array of adverse effects in the nervous system, including disruption of hippocampal-dependent plasticity and cognition.
Of relevance to this proposal, GCs can also compromise the ability of hippocampal and cortical neurons to survive an array of necrotic neurological insults.
Amid this picture of deleterious effects, there is the accepted paradigm in which GCs are seemingly protective in the context of necrot…
UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA
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