CORDIS Project
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This project investigates the cellular diversity in glioblastoma tumors using advanced techniques like single cell RNA sequencing. By analyzing patient samples and models, it aims to understand how different cell types respond to treatments and to identify new cellular states that could inform more effective therapeuti…
Cellular heterogeneity is a fundamental property of glioblastoma (GBM) tumors and presents a major barrier for therapeutics.
During the past six years we characterized this heterogeneity in glioblastoma, and in other types of glioma, using single cell RNA-seq (scRNA-seq).
We found consistent patterns of heterogeneity across patients, such that each tumor harbors multiple subpopulations of cells that resemble neurodevelopmental cell types.
The consistency of these cellular states across patients…
WEIZMANN INSTITUTE OF SCIENCE
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