CORDIS Project
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This project focuses on Group A Streptococcus, a bacterium responsible for various diseases. It aims to identify GAS virulence factors that affect the host's immune response through autophagy and explore the role of autophagy in fighting infections caused by this pathogen.
Group AStreptococcus (GAS) is a predominant Gram-positive bacterium causing a substantial burden of diseases in humans.
Autophagy is a starvation-induced response that provides nutrients by degrading long-living proteins and recycling intracellular organelles.
In 2004, autophagy was identified as a new immune mechanism for killing and clearing invading GAS in epithelial cells.
It is regulated by host proteins such as Beclin1, ATG 5, ATG6 and LC3.
On the other hand, host proteases such as calpain…
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
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