CORDIS Project
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This project investigates the role of intercrypt goblet cells in maintaining the mucus barrier in the intestine, focusing on their relationship with microbiota and inflammatory bowel diseases like ulcerative colitis. It combines animal and human studies to uncover the molecular mechanisms behind goblet cell dysfunction…
The mucus layer produced by the goblet cells (GCs), provides the barrier between the microbiota and the intestine preventing the occurrence of the inflammation process.
Indeed, alteration in microbiota towards mucus degrading bacteria, are often associated with impaired mucus barrier properties and inflammatory bowel diseases, such as ulcerative colitis (UC).
Although, the exact mechanisms behind UC are not understood, defects in luminal compartmentalisation of bacteria by mucus could play a maj…
UNIVERSITEIT UTRECHT
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UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
Sweden, Goeteborg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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