CORDIS Project
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The GameofGates project investigates the role of Solute Carrier proteins in cellular processes, particularly their impact on drug resistance and metabolism. By mapping genetic interactions, it aims to uncover how these proteins regulate cellular access to resources.
Chemical exchange between cells and their environment occurs at cellular membranes, the interface where biology meets chemistry.
Studying mechanisms of drug resistance, I realized that SoLute Carrier proteins (SLCs), not only represent the major class of small molecule transporters, but that they are encoded by one of the most neglected group of human genes. I identified a case where an SLC controls the activity of mTOR, suggesting that other SLCs may be involved in signalling.
This formed the b…
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